Rhodiola & Stress Reduction

Stress is the number one contributor to premature ageing. Prevention is better than a cure.

Here are more reasons to get your clients onto the Regul8’s Relax, to help to keep the body strong and resilient, against the destructive effect of stress. Also, to prime your immune system.

Chronic or long-term stress can lead to symptoms like anxiety, depression, sleep problems and weak immune system, as well as disease status such as cardiovascular and metabolic. Stress resistance is believed to be related to hallmarks of ageing, including altered intra-and intercellular communication, dysregulated nutrient sensing, mitochondrial health, cell senescence, stem cell exhaustion, genomic instability (DNA damage), telomere attrition, and certain patterns of gene expression. Increasing data indicate an intriguing relationship between stress resistance and slowed ageing.

How can Rhodiola rosea extract help?

In addition to its multiplex stress-protective activity, Rhodiola rosea extracts have recently demonstrated its anti-ageing, anti-inflammation, immunostimulating, and DNA repair. Molecular mechanisms of Rhodiola rosea extract’s action have been studied along with one of its bioactive compounds, salidroside.

Results from these studies have revealed its wide variety of other medicinal properties and/or biological activities, which include antioxidant, and anti-viral, as well as increasing immunity, enhancing DNA repair, and modulating adaptation to hypoxia and angiogenesis. The unique biological activities of Rhodiola Rosea extracts can enhance normal physiological functions.

More than 140 compounds have been isolated from roots and rhizomes of Rhodiola species, including monoterpene alcohols and their glycosides, cyanogenicglycosides, arylglycosides, phenylethanoids, phenylpropanoids and their glycosides, flavonoids, flavonolignans, proanthocyanidins and gallic acid derivatives.

Rhodiola and immunity

Rhodiola rosea extracts have been documented with immunostimulating activity both in vitro in human peripheral blood mononuclear cells (PBMCs) and in vivo in animals. Rhodiola rosea extracts increased total CD3+ and memory CD4+ T cell pools but decreased the number and function of cytotoxic CD8+ T cells in a mouse model of caecal ligation and puncture-induced sepsis. Rhodiola rosea extracts increased production of Th1 cytokines (i.e., IFN-γ, IL-2 and IL-12), reduced spleen and thymus lymphocyte apoptosis and enhanced their survival through downregulation of tumour necrosis factor-α-induced protein 8-like-2 expression in septic rats. Salidroside not only improved total T cell (CD3+) and Th1 cells (CD4+), but also promoted the production of immunoglobulins (total IgG, IgG1 and IgG2α).